Dr. Rizwanul Haque

Dr. Haque in the area of Immunology and Cancer Biology and has special focus on Stem Cells to treat immune mediated diseases. Currently, Dr. Haque is involved in the generation of immune cells, mainly T cells and Treg cells from stem cells, which can be used for adoptive immunotherapy and likely to contribute toward treatments of cancers, asthma, and autoimmune diseases. His breakthrough research and his background are significant for developing therapeutic immune cells to treat cancer. Dr. Haque has made significant contributions, which are evident from his 46 publications in a variety of top-class scientific journals and his research citation of more than 2700 times by other research groups worldwide, with an h-index of 19 and i10 index of 25. He is the Principal Investigator (PI) in SERB and DST-FIST funded research projects and served as Co-PI in 5 research projects in the USA.

Research:

• Dissecting the role of Telomerase complex and Notch signaling in the modulation of Cancer and Rheumatoid arthritis.
• Development of antigen based cellular vaccine for cancer and other infectious diseases.
• Generation of tumor specific Immune cells from stem cells.

• publications :
1. Rai NK, Panjwani G, Rizwanul Haque, Ghosh AK, Sharma L.K*. (2021) Analysis of mitochondrial DNA copy number variation in blood and tissue samples of metastatic breast cancer Patients. (Accept for publication Biochemistry and Biophysics Reports, impact factor-1.6.)
2. Neeraj Kumar Rai, Meenakshi Tiwari, Rizwanul Haque, Lokendra Kumar Sharma. "Differential regulation of mitochondrial complex I and oxidative stress based on metastatic potential of colon cancer cells". Oncology letters. 2020 Dec;20(6):313. doi: 10.3892/ol.2020.12176. Epub 2020 Sep 30, Impact factor-2.3, Print ISSN: 1792-1074
3. Archana Chaudhary, Rizwanul Haque. Promising Therapeutic Targets to halt the Global Pandemic of SARS CoV-2. International Journal of Applied Biology and Pharmaceutical Technology 11 (2020): Vol.3, 144-159. Impact Factor (1.7), ISSN: 0976-4550
4. Chaudhary A & Rizwanul Haque. Therapeutic Role of Arsenic Trioxide in Cancer Prevention. Archives of Medicine, 2020, Vol. 12 Iss: 3;14, 1-9, DOI: 10.36648/1989-5216.12.4.315, Impact Factor (1.0), ISSN 1989-5216.
5. Prakash A, Kumar V, Lynn AM, Rizwanul Haque. Insights into the DNA binding induced thermal stabilization of transcription factor FOXP3. J Biomol Struct Dyn. 2018 Jul 26:1-27. doi:10.1080/07391102.2018.1486228. Impact Factor: 3.54, ISSN 0739-1102.
6. Sadaf N, Kumar N, Ali M, Ali V, Bimal S, Rizwanul Haque. Arsenic trioxide induces apoptosis and inhibits the growth of human liver cancer cells. Life Sci. 2018 Jul 15;205:9-17. doi: 10.1016/j.lfs.2018.05.006. Impact Factor: 3.647, ISSN 0024-3205
7. Ghanshyam Kumar Satyapala, Santosh Kumar Mishraa, Amrita Srivastavab, Rajesh Kumar Ranjanc, Krishna Prakasha, Rizwanul Haque, Nitish Kumar. Possible bioremediation of arsenic toxicity by isolating indigenous bacteria from the middle Gangetic plain of Bihar, India. Biotechnology Reports. 2018. 2018 Feb 8;17:117-125. doi: 10.1016/j.btre.2018.02.002 Impact Factor: 4.47, ISSN 2215-017X
8. Rizwanul Haque, Chaudhary A, Sadaf N. Immunomodulatory role of arsenic on regulatory T cells. Endocr Metab Immune Disord Drug Targets. 2017 Aug 17. doi: 10.2174/1871530317666170818114454. Impact Factor- 1.973, ISSN:1871-5303(Print).
9. Vinod Kumar, Neeraj Tiwari, Mallikarjun Rao Gedda, Rizwanul Haque & Rakesh Singh (2017). Leishmania donovani infection activates TLR 2, 4 expressions and TGF-β mediated apoptosis in renal tissues. Brazilian Journal of Infectious Diseases, Braz J Infect Dis. 2017 Sep - Oct;21(5):545-549. Impact Factor: 2.223. ISSN: 1413-8670.
10. Rizwanul Haque, Jianyong Song , Mohammad Haque, Fengyang Lei , Praneet Sandhu , Bing Ni, Songguo Zheng , Deyu Fang , Jin‐Ming Yang and Jianxun Song. c‐Myc‐Induced Survivin Is Essential for Promoting the Notch‐Dependent T Cell Differentiation from Hematopoietic Stem Cells. Genes (Basel). 2017 Mar 6;8(3). pii: E97. doi: 10.3390/genes8030097. PMID: 28272325, Impact Factor: 3.759, ISSN 2073-4425 API: 28 UGC ID- 13159
11. Saif Ahmad, Nehal M. El-Sherbiny, Mohammad Sarwar Jamal, Faisal A. Al-Zahrani, Rizwanul Haque, Raziuddin Khan, Sayed Kashif Zaidi, Mohammed H. Al-Qahtani, Gregory I. Liou, Kanchan Bhatia. (2016). Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy. Journal of Neuroimmunology. 295–296, 2016 47–53. Impact Factor: 2.832. ISSN: 0165-5728.
12. Ashraf, G. M., Perveen, A., Zaidi, S. K., Tabrez, S., Shakil, S., Ahmad, A., Rizwanul Haque., Ahsan, J., Kamal, M. A., B anu, N. (2015). Integrating qualitative and quantitative tools for the detection and identification of lectins in major human diseases. Protein and Peptide Letters, 22(11):954-62. Impact Factor: 1.130. ISSN: 1875-5305 (Online), ISSN: 0929-8665 (Print).
13. Nadra Sadaf, Jawaid Ahsan, Saif Ahmad, Rizwanul Haque. Mitochondria: A Key Player in Stem Cell Fate. Cell Biology. 2015; 3(2-1): 31-37. Impact Factor:? ISSN: 2330-0175 (Print); ISSN: 2330-0183 (Online).
14. Saif Ahmad, Nehal M. Elsherbiny, Rizwanul Haque, M Badruzzaman Khan, Tauheed Ishrat, Zahoor A. Shah, Mohammad M. Khan, Mehboob Ali, Arshad Jamal, Deepshikha Pande Katare, Gregory I. Liou, Kanchan Bhatia. Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke. Neurotoxicology. 2014: 45: 100-10. Impact Factor: 3.263, Online ISSN: 0161-813X.
15. Mikerov AN, Phelps DS, Gan X, Umstead TM, Rizwanul Haque, Wang G, Floros J. Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns. Toxicol Lett. 2014, Oct 15;230(2):333-344. pii: S0378-4274(14)00167-2, Impact Factor: 3.499, Online ISSN: 0378-4274.
16. Mehboob Ali, Sagheer Ahmed Khan, Peter S Chang, Rizwanul Haque Kanchan Bhatia and Saif Ahmad. Habb-e-Asgand, polyherbal Unani formulation protects liver and antioxidative enzymes against paracetamol induced hepatotoxicity. Pharmaceutical Biology, 2014, 52(4): 506–515 Impact Factor: 2.490, Online ISSN: 1744-5116,
17. Lei F, Song J, Rizwanul Haque, Haque M, Xiong X, Fang D, Croft M, Song J. Regulation of A1 by OX40 Contributes to CD8(+) T Cell Survival and Anti-Tumor Activity. PLoS One. 2013 Aug 1;8(8): Impact Factor: 2.870, eISSN-1932-6203.
18. Lei F, Song J, Rizwanul Haque, Xiong X, Fang D, Wu Y, Lens SM, Croft M, Song J. Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol. 2013 Jul;43(7):1914-24. Impact Factor: 4.695, Online ISSN: 1521-4141.
19. Rizwanul Haque, Fengyang Lei, Baohua Zhao, Yuzhang Wu and Jianxun Song. Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity”. J Immunology. 2012 Aug 1;189(3):1228-36. Impact Factor: 4.340, ISSN 0022-1767.
20. Fengyang Lei, Rizwanul Haque, Xiaofang Xiong, and Jianxun Song. Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes. J. Vis. Exp. (63), e3986, 1-9, DOI: 10.3791/3986 (2012). Impact Factor: 1.1, ISSN: 1940-087X.
21. Saif Ahmad, M Badruzzaman Khan, Hoda MN, Kanchan Bhatia, Rizwanul Haque, Inayat Salim Fazili, Arshad Jamal, Jafar Salamat Khan, Deepshikha Pande Katare. (2011). “Neuroprotective Effect of Sesame Seed Oil in 6-Hydroxydopamine Induced Neurotoxicity in Mice Model: Cellular, Biochemical and Neurochemical Evidence. Neurochemical Research. 2012 Mar;37(3):516-26. Impact Factor: 2.782, ISSN: 1573-6903.
22. Rizwanul Haque, Dylan Lei FY, Xiaofang Xiong and Jianxun Song. (2011). “The Regulation of FoxP3-Expressing Regulatory T Cells”. Endocrine, Metabolic & Immune Disorders - Drug Targets. 2011 Dec;11 (4):334-46. PMID: 21696363. Impact Factor: 1.104, Print ISSN:0008-5472.
23. Fengyang Lei, Baohua Zhao, Rizwanul Haque, Xiaofang Xiong Lynn Budgeon, Neil D. Christensen Yuzhang Wu and Jianxun Song. “In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance”. Cancer Res. 2011 Jul 15; 71 (14): 4742-7. PMID: 21628492. Impact Factor: 7.070, ISSN 1871-5303. Published as a priority report* and captured on cover page. Published short, definitive reports of findings of high impact, significance, and timeliness. The above works has been reported world wide in science news media and captured by many websites (Stem cells are potential source of cancer fighting T cells).
24. Mehboob Ali, Todd M Umstead, Rizwanul Haque, Anatoly N Mikerov, Willard M. Freeman Joanna Floros and David S Phelps. (2010). Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice. Proteome science. 8:34. PMID: 20565803. Impact Factor: 1.746, ISSN 1477-5956.
25. Rizwanul Haque, Fengyang Lei, Xiaofang Xiong, Yuzhang Wu, and Jianxun Song. (2010). Foxp3 and Bcl-xl cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Research & Therapy, 12; 12(2): R66. 1-11 PMID: 20384988. Impact Factor: 4.240, ISSN 1477-5956.
26. Saif Ahmad, Inayat S. Fazili, Rizwanul Haque, Samdun Nisa Khan and Malik Zainul Abdin. (2010). Standardization and estimation of nitrate reductase activity in the leaves of Ammi majus L. (Bishops weed) in relation to sulphur deficiency and seed yield. Australian Journal of Crop Science. 4(7):515-522. Impact Factor: 1.63, ISSN 1835-2707.
27. Dylan Lei FY#, Rizwanul Haque#, (#: First authors equally contributed) Lauren Weiler, Kent Varan and Jianxun Song. (2009). T lineage differentiation from induced pluripotent stem (iPS) cell. Cellular Immunology. 260(1): 1-5. Published as a Rapid communication. Impact Factor: 3.291, ISSN: 0008-8749.Rapid Communications are brief, definitive reports of highly significant and timely findings in the field
28. Rizwanul Haque, Todd M. Umstead, Kwangmi Ahn, David S. Phelps and Joanna Floros. (2009). Effect of low doses of lipopolysaccharide priors to ozone exposure in bronchoalveolar lavage: Differences between wild type and surfactant protein A-deficient mice. Pneumon; 22(2): 13-25. Impact Factor: ?, ISSN 1105-848X
29. Baohua Zhao, Aihua Song, Rizwanul Haque, Fengyang Lei, Lauren Weiler, Xiaofang Xiong, Yuzhang Wu, Michael Croft, and Jianxun Song (2009). Cooperation Between Molecular Targets of Costimulation in Promoting T Cell Persistence and Tumor Regression. Journal of Immunology 182(11):6744-6752. Impact Factor: 4.9340, ISSN 0022-1767.
30. Rizwanul Haque, Todd M Umstead, Willard M. Freeman, David S. Phelps & Joanna Floros. (2009). The Impact of Surfactant Protein-A on Ozone-Induced Changes in the Mouse Bronchoalveolar Lavage Proteome. Proteome science 26; 7:12. 1-22, Impact Factor: 1.746, ISSN: 1477-5956.
31. Anatoly N. Mikerov, Rizwanul Haque, Xiaozhuang Gan, Xiaoxuan Guo, David S. Phelps, and Joanna Floros. (2008). Ablation of SP-A has a negative impact on the susceptibility of mice to Klebsiella pneumoniae infection after ozone exposure: sex differences. Respiratory Research. 4; 9:77. Impact Factor: 3.890, ISSN 1465-9921.
32. Song JX, Tylan Lei FY, Xiong XF and Rizwanul Haque. (2008). Intracellular signals of T cell costimulation. Cellular & Molecular Immunology. 2008 Aug; 5(4):239-247. Impact Factor: 7-110, ISSN 1672-7681.
33. Rizwanul Haque, Todd M. Umstead, Padmavathi Ponnuru, Xiaoxuan Guo, Samuel Hawgood, David S. Phelps, and Joanna Floros. (2007). “The Effect of Acute Ozone Exposure on Lung Inflammation in Surfactant Protein-A-Deficient Mice”, Toxicology and Applied Pharmacology, 220, 72-82. Impact Factor: 3.740, ISSN 0041-008X.
34. Rizwanul Haque, Bin-Hafeez B, Parvez. S, Pandey S, Saeed I, Ali. M & Raisuddin S. (2003). Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide induced biochemical toxicity. Human and Experimental Toxicology, 22 (9): 473-480. Impact Factor: 2.080, ISSN 0960-3271.
35. Bin-Hafeez B, Rizwanul Haque, Parvez. S, Pandey. S, Saeed I & Raisuddin S. (2003). Immunomodulatory effect of Trigonella foenum graecum in mice. International Immunopharmacology. 3, 257-265. Impact Factor: 3.380, ISSN 1567-5769.
36. Parvez S, Sayeed I, Pandey S, Ahmad A, Ahmad I, Bin-Hafeez B, Rizwanul Haque & Raisuddin S. (2003). Modulatory effect of copper on non-enzymatic antioxidants in freshwater fish Channa punctatus (Bloch.). Biological Trace Element Research, 93 (1-3): 237-48. Impact Factor: 2.431, ISSN 0163-4984.
37. Pandey S, Parvez S, Sayeed I, Rizwanul Haque, Bin-Hafeez B & Raisuddin S. (2003). Biomarkers of Oxidative Stress: Biomarkers of Oxidative Stress: A Comparative Study of River Yamuna Fish Wallago attu (Bl. & Schn.). The Science of The Total Environment. 309: 105-115. Impact Factor: 5.589, ISSN 0048-9697.
38. Sayeed I, Parvez S, Pandey S, Bin-Hafeez B, Rizwanul Haque and Raisuddin S. (2003). Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch. Ecotoxicology and Environmental Safety 56 (2): 295-301. Impact Factor: 4.710, ISSN 0147-6513.
39. Rizwanul Haque, Bin-Hafeez B, Ahmad I, Parvez, Pandey S & Raisuddin S. (2001). Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Human and Experimental Toxicology, 20; 643-50. Impact Factor: 2.080, ISSN 0960-3271.
40. Bin-Hafeez B, Ahmad I, Rizwanul Haque & Raisuddin S. (2001). Protective effect of Cassia occidentalis L. on cyclophosphamide-induced suppression of humoral immunity in mice. Journal of Ethnopharmacology, 75; 13-18. Impact Factor: 3.414, ISSN 0378-8741.
41. Pandey S, Ahmad I, Parvez S, Bin-Hafeez B. Rizwanul Haque & Raisuddin S. (2001). Effect of endosulfan on anti oxidants of freshwater fish Channa punctatus Bloch. 1. Protection against lipid peroxidation in liver by copper pre-exposure. Archives of Environmental contamination and Toxicology, 41; 345-352. Impact Factor: 2.240, ISSN 0090-4341.

Book Chapter
1. Rizwanul Haque, Dylan Lei FY and Jianxun Song. Stem Cell-Based Cellular Therapy in Rheumatoid Arthritis. Autoimmune Diseases". 2012, Chapter: 13, Page number 319-342, http://dx.doi.org/10.5772/47804, ISBN 980-953-307-109-6. INTECH.
2. Fengyang Lei, Rizwanul Haque, Xiaofang Xiong and Jianxun Song. Generation of Antigen-Specific T lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy, Stem Cells and Cancer Stem Cells, Volume 10, 2013, pp 105-121. ISBN: 978-94-007-6261-9, Springer.
3. Lei F, Rizwanul Haque, Xiong X, Song J. Modulation of Autoimmune Diseases by iPS Cells. Methods Mol Biol. 2014;1213:365-77. doi: 10.1007/978-1-4939-1453-1_30. ISSN 1064-3745. Springer.
4. Rizwanul Haque & Manish Kumar. To study the status of HSCs in diseases versus normal conditions. Human Implication of Biotechnology, 2017, Chapter 10, page number 91-106, ISBN: 978-81-8329-862-9. Shree Publisher and Distributor, New Delhi,
5. Mehboob Ali, Rizwanul Haque and Saif Ahmad Khan. Docosahexaenoic Acid (DHA): A Dietary Supplement With Promising Anticancer Potential. The Molecular Nutrition of Fats, 2018, Chapter 30, page number 389-396, ISBN: 978-0-12-811297-7, Academic Press is an imprint of Elsevier.
6. Archana Chaudhri & Rizwanul Haque. The Healing Art of Arsenic in Various Malignancies. Arsenic Toxicity: Challenges and Solutions, 2021 Springer Dr. N Kumar (Ed), Accepted for publication. ISBN: 978-981-336-067-9
Full length paper in Conference Proceeding:
7. Rizwanul Haque, Generation of immune cells from induced pluripotent stem (iPS) cell. Published in souvenir, National Conference on Genetics and Stem Cell Research. Department of Pathology / Lab medicine, AIIMS, Patna, November 15 2014. Paper IV, page 21-24.
News Work captured by Science Last Fortnight: Recent work published in Life Science journal got noticed by the editor of in CURRENT SCIENCE as Toxin Turned Medicine (Arsenic to cure liver cancer). Page 195-106, CURRENT SCIENCE, VOL. 115, NO. 2, 25 JULY 2018

• Awards :
1. Invited as a Chief Guest ERA University, Lucknow in Guest lecture by Dr. Saif Khan from Barrow Neurological Institute, USA. October 2019
2. Inaugurated Exhibition on Application of Stem cell Technology at Patna Women’s College, Patna University to commemorate Nation Science Day on 23-02-2017.
3. 2016: Invited to participate in valedictory function on one day symposium Technical Rajbhasa, in the Regional Research Institute of Unani Medicine, Patna, CCRUM, Ministry of AYUSH, Govt. of India, 30-03-2016 Topic: Clean India & Healthy India
4. 2011: Recipient of American Association of Immunologist Travel Grant for 98th Annual Meeting of IMMUNOLOGY 2011 for oral presentation, May 13-17, San Francisco, USA.
5. 2010: Recipient of 2010 American Association of Immunologist Travel Grant for the 14th International Congress of Immunology held in Kobe, Japan, August 22-27, 2010.
6. 2009: Nomination & Recognition Award for best postdoctoral fellow of the year 2009 to present his work in Data & Dine 2009, held at Penn State University College of Medicine.
7. 2009: Recognition award: Certificate of recognition and appreciation for the commitment for 5 years of service by Penn State Milton Hershey Medical Center, Penn State College of Medicine held in May 2009
8. 2007: Invited oral presenters: 2007 DIGE user meeting fully sponsored by GE Healthcare held at Athens Georgia on January 17-18, 2007.
9. 2006: Poster selected discussions in a special section of poster discussion at Physiological Genomics and Proteomics of Lung Disease held at Fort Lauderdale, Florida on November 2-5, 2006.
10. 2003-2001: Recipient of the award of Senior Research Fellowship (SRF) from Council for Scientific and Industrial Research (CSIR), Government of India from Nov 2001 to July 2003.
11. 2001-1999: Recipient of Senior Research Fellowship from the Central Council for Research in Unani Medicine (CCRUM), Government of India from Aug 1999 to Nov 2001.
12. 2000-2001: Awarded Sports Science Fellowship, Govt. of India for the year 2000-2001.
13. 1996-1994: Received Bharat Sewa Trust Merit Scholarship, Govt. of India 1994-1996.
14. 1993: Secured first position in college at 10+2 levels 1993.
• Projects:
Ongoing Grants:
1. SCIENCE & ENGINEERING RESEARCH BOARD (SERB), 2018-2021, Rs. 31.5.lakh, Title: "MECHANISM OF TELOMERASE REGULATION IN RESPONSE OF ARSENIC IN LIVER CANCER".
2. Departmental Grant DST-FIST, DBT, Govt. of India: Rizwanul Haque, Department of Biotechnology, SEBES, Central University of South Bihar, FIST- PROJECT (Level-1), SR/FST/LS-I/2019/513, Total Budget, Rs. 59.0 lakhs, Division: R & D Infrastructure Programme or Scheme :FIST Life Sciences Level I.
Grants: Co-investigator in USA:
1. 10/01/2010-09/30/2012, W. W. Smith Charitable Trust, $ 100,000. Tile: Impact of Tyrosine-specific CTLs from iPS cells on melanoma.
2. 07/2010-06/2012, Melanoma Research Foundation, $ 100,000. Title: Impact of iPS cell-derived highly reactive T lymphocytes on melanoma.
3. 01/01/2011-12/31/2011, Barsumian Trust, $ 25,000. Title: Impact of iPS derived regulatory T cells on Lupus.
4. 7/1/2008 – 6/30/2010, Pennsylvania Department of Health, $ 50,000. Title: Interaction between Survivin and Aurora B in Primary T Lymphocytes.
5. 07/01/2008-0630/2009: St. Baldric’s Foundation, $ 50,000. Generation of tumor-specific CTLs from HSC.

1. Head: Department of Biotechnology (2018 to till date)
2. Member: Academic Council 2017-till date
3. Elected Member of University Court 2019 – till date
4. Chair: Departmental Committee (July 2018 to till date)
5. Chair: Department Research Degree committee (July 2018 to till date)
6. Chair: Departmental Purchase committee (Sept. 2018 to till date)
7. Chair: Institutional Biosafety Committee 2012 to till date
8. Chair: BOS Department of Biotechnology
9. Cognate Member: BOS, Department of Life Science (2019- till date)
10. Cognate Member: BOS, Department of Pharmacy (2020-till date)
11. Member: School Board of School of Earth Biological and Environmental Science, CUSB (2021-till date)
12. Member: Finalization committee of MoU between CUSB and RMRI-ICMR, Patna
13. Member: Internal Compliance Committee (2020-till date)
14. Member: Grievance Redressal Committee for teacher (2019-till date)
15. Member: Anti Ragging Committee (2018-till date)
16. Member: school Research Degree committee
17. Member: University Research Committee
18. Member: School Project Approval Committee
19. Member: CUSB Innovation Club Coordination Committee
20. Member: CUSB GIAN Coordination Committee
21. Member: ST/SC cell (2017-till date)
22. Coordinator: SKILL VIGYAN PROGRAMME (2019-till date)